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Tirzepatide acts on two key pathways that regulate metabolism and appetite:
GLP-1 (glucagon-like peptide-1): This hormone increases insulin secretion when blood sugar is high and suppresses the release of glucagon, which helps control blood sugar. It also slows down how quickly the stomach empties, making you feel full longer.
- GIP (glucose-dependent insulinotropic polypeptide): This hormone also stimulates insulin release in a glucose-dependent manner. By activating both GIP and GLP-1 receptors, tirzepatide amplifies these effects, leading to superior blood sugar control and significant weight loss.
Clinical trials have demonstrated the effectiveness of tirzepatide in both its approved uses:
- Weight Management: In the SURMOUNT trials for chronic weight management, participants without diabetes lost an average of 15% to 21% of their starting body weight over 72 weeks (about 16.5 months).
